Mitral Valve Prolapse
Magnesium Deficiency and Mitral Valve Prolapse
Magnesium plays a significant role in heart health and has been linked to the management of mitral valve prolapse (MVP). MVP is a condition where the mitral valve in the heart becomes floppy or doesn’t close properly, potentially leading to symptoms like palpitations, chest pain, fatigue, and shortness of breath. Research suggests that magnesium deficiency is common among individuals with MVP.
Magnesium is essential for maintaining cardiovascular health, as it regulates heart rhythm, supports muscle function, and helps manage stress responses. Studies have shown that magnesium supplementation may play a role in alleviating symptoms of MVP, such as anxiety, palpitations, and fatigue.
When considering magnesium supplementation or dietary changes for MVP, it’s always best to consult with a healthcare provider to determine the appropriate approach for individual health and medical needs.
Following are research references related to Magnesium and MVP.
Amoozgar H, Rafizadeh H, Ajami G, Borzoee M. The prevalence of hypomagnesaemia in pediatric patients with mitral valve prolapse syndrome and the effect of mg therapy. Int Cardiovasc Res J. 2012 Sep;6(3):92-5. https://pubmed.ncbi.nlm.nih.gov/24757600/ CMER comment: Author’s definition of low magnesium (hypomagnesemia) at 1.5 mg/dl is quite low, lower than the more usual definition of below 1.8 or even more recently, below 2.1 mg/dl. If these % results were redone using these more appropriate definitions of low magnesium, more of their MVP patients would be shown to be magnesium deficient. Also, their trial of oral magnesium supplements of 5 weeks is too short. Fully raising serum magnesium with oral magnesium therapy typically takes 3 months or more.
Martynov AI, Akatova EV. [Fifteen years experience of the use of magnesium preparations in patients with mitral valve prolapse]. Kardiologiia. 2011;51(6):60-5. Russian. https://pubmed.ncbi.nlm.nih.gov/21878073/
Bobrowski W, Nowak A, et al. The importance of magnesium status in the pathophysiology of mitral valve prolapse. Magnes Res. 2005;18(1):35-52. https://pubmed.ncbi.nlm.nih.gov/15945614/
Kitliński M, Stepniewski M, Nessler J, Konduracka E, Solarska K, Piwowarska W, Erhardt L. Is magnesium deficit in lymphocytes a part of the mitral valve prolapse syndrome? Magnes Res. 2004 Mar;17(1):39-45. https://pubmed.ncbi.nlm.nih.gov/15083568/
Bobkowski W, Siwinska A, et al. [Electrolyte abnormalities and ventricular arrhythmias in children with mitral valve prolapse]. Pol Merkuriusz Lek. 2001;11(62):125-8. https://pubmed.ncbi.nlm.nih.gov/11757209/
Devereux RB, Jones EC, et al. Prevalence and correlates of mitral valve prolapse in a population-based sample of American Indians: the Strong Heart Study. Am J Med. 2001;111(9):679-85. https://pubmed.ncbi.nlm.nih.gov/11747846/
Fauchier JP, Babuty D, et al. [Mitral valve prolapse, arrhythmias and sudden death]. Arch Mal Coeur Vaiss. 2000;93(12):1541-7. https://pubmed.ncbi.nlm.nih.gov/11211450/
Kitlinski M, Konduracka E, et al. [Evaluation of magnesium cation levels in serum of patients with mitral valve prolapse syndrome]. Folia Med Cracov. 2000;41(3-4):17-24. https://pubmed.ncbi.nlm.nih.gov/11339012/
Martynov AI, Stepura OB, et al. [New approaches to the treatment of patients with idiopathic mitral valve prolapse]. Ter Arkh. 2000;72(9):67-70. https://pubmed.ncbi.nlm.nih.gov/11076423/
Disse S, Abergel E, et al. Mapping of a first locus for autosomal dominant myxomatous mitral-valve prolapse to chromosome 16p11.2-p12.1. Am J Hum Genet. 1999;65(5):1242-51. https://pubmed.ncbi.nlm.nih.gov/10521289/
Durlach J, Bac P, et al. Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance. Magnes Res. 1997;10(2):169-95. https://pubmed.ncbi.nlm.nih.gov/9368238/
Lichodziejewska B, Klos J, et al. Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation. Am J Cardiol. 1997;79(6):768-72. https://pubmed.ncbi.nlm.nih.gov/9070556/
Durlach J. Primary mitral valve prolapse: a clinical form of primary magnesium deficit. Magnes Res. 1994;7(3-4):339-40. https://pubmed.ncbi.nlm.nih.gov/7786696/
Durlach J, Durlach V, et al. Magnesium and blood pressure. II. Clinical studies. Magnes Res. 1992;5(2):147-53. https://pubmed.ncbi.nlm.nih.gov/1390008/
Coghlan HC, Natello G. Erythrocyte magnesium in symptomatic patients with primary mitral valve prolapse: relationship to symptoms, mitral leaflet thickness, joint hypermobility and autonomic regulation. Magnes Trace Elem. 1991;10(2-4):205-14. https://pubmed.ncbi.nlm.nih.gov/1844553/
Zeana CD. Recent data on mitral valve prolapse and magnesium deficit. Magnes Res. 1988;1(3-4):203-11. https://pubmed.ncbi.nlm.nih.gov/3079420/
Cohen L, Laor A, et al. Renal excretion of lactate and magnesium in mitral valve prolapse. Magnes Res. 1988;1(1-2):75-8. https://pubmed.ncbi.nlm.nih.gov/3274927/
Klos J, Lichodziejewska B, et al. [Results of the compensatory treatment of disorders of magnesium and calcium metabolism in mitral valve prolapse syndrome]. Pol Tyg Lek. 1988;43(41):1330-3. https://pubmed.ncbi.nlm.nih.gov/3244597/
Klos J, Lichodziejewska B, et al. [Disorders of magnesium and calcium metabolism in mitral valve prolapse syndrome]. Pol Tyg Lek. 1988;43(41):1325-9. https://pubmed.ncbi.nlm.nih.gov/3244596/
Cohen L, Bitterman H, et al. Idiopathic magnesium deficiency in mitral valve prolapse. Am J Cardiol. 1986;57(6):486-7. https://pubmed.ncbi.nlm.nih.gov/3946269/
Durlach J, Durlach V. Idiopathic mitral valve prolapse and magnesium: state of the art. Magnesium Bul. 1986;:156-169. https://www.magnesium-ges.de/jdownloads/Literatur/Durlach/durlach_1986_idiopathic_mitral_valve_prolapse_and_magnesium_498.pdf
Frances Y, Collet F, et al. Long-term follow-up of mitral valve prolapse and latent tetany. Preliminary data. Magnesium. 1986;5(3-4):175-81. https://pubmed.ncbi.nlm.nih.gov/2873272/
Galland LD, Baker SM, et al. Magnesium deficiency in the pathogenesis of mitral valve prolapse. Magnesium. 1986;5(3-4):165-74. https://pubmed.ncbi.nlm.nih.gov/3014234/
Durlach J, Lutfalla G, et al. Latent tetany and mitral valve prolapse due to chronic primary magnesium deficit. Magnesium Deficiency Physiopathology and Treatment Implications. Basel, Switzerland, Karger; 1985:102-112. https://karger.com/books/book/3451/chapter-abstract/11752740/Latent-Tetany-and-Mitral-Valve-Prolapse-due-to?redirectedFrom=PDF
Galland L. Magnesium deficiency in mitral valve prolapse. Magnesium Deficiency Physiopathology and Treatment Implications. Basel, Switzerland, Karger; 1985:117-119. https://doi.org/10.1159/000410559
Simoes Fernandes J, Pereira T, et al. Therapeutic effect of a magnesium salt in patients suffering from mitral valvular prolapse and latent tetany. Magnesium. 1985;4(5-6):283-90. https://pubmed.ncbi.nlm.nih.gov/3914582/
Zeana C, Briciu M, et al. Considerations on the pathogenesis of mitral valve prolapse. Med Interne. 1985;23(3):165-70. https://pubmed.ncbi.nlm.nih.gov/4048797/
Gerard R, Luccioni R, et al. [Mitral valve prolapse and spasmophilia in the adult]. Arch Mal Coeur Vaiss. 1979;72(7):715-20. https://pubmed.ncbi.nlm.nih.gov/117769/
Kachru RB, Telischi M, et al. The HLA antigens and ABO blood groups in an American Black population with mitral valve prolapse. Tissue Antigens. 1979;14(3):256-60. https://pubmed.ncbi.nlm.nih.gov/524338/
Braun WE, Ronan J, et al. HLA antigens in mitral valve prolapse. Transplant Proc. 1977;9(4):1869-71. https://pubmed.ncbi.nlm.nih.gov/601847/