Transdermal Magnesium research

Transdermal Magnesium research is promising, but in its infancy.

In 2012 Dr. Rosanoff, creator and Director of Research at CMER, developed a transdermal magnesium cream and had it tested in the research laboratory of Prof. Mahavir Chougule at the University of Hawaii School of Pharmacy in Hilo, HI.  He found that magnesium from this cream-mixture did cross human cadaver skin while an aqueous solution of the same magnesium chloride compound did not.   They presented this research at the International Magnesium Conference, Merida Mexico in 2012.    Since Dr. Rosanoff applied for and was granted US. Patent No.  US 10,258,646 B2 on this cream and it was tested against a placebo cream in a human randomly controlled trial that showed magnesium from this cream raised serum magnesium levels in two weeks about the same as oral magnesium supplements raise serum magnesium in three months (1).  This was a small study and its findings need to be confirmed.

This and other transdermal preparations have been used for several years now, and many people report help with cramps, pain, stiffness, chronic fatigue syndrome and fibromyalgia, Parkinson’s as well as other health issues.  Research in transdermal magnesium and these symptoms/conditions is meager, and we hope that researchers will explore the potential of this safe, comfortable, non-oral way to supplement one’s magnesium.

Dr. Rosanoff’s cream can be purchased at

Links and Reference:

  1. Kass L, Rosanoff A, Tanner A, et al. Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study. PloS one 2017;12(4):e0174817. doi: 10.1371/journal.pone.0174817

Buy Dr Rossanoff’s Book

The Magnesium Factor: How One Simple Nutrient Can Prevent, Treat, and Reverse High Blood Pressure, Heart Disease, Diabetes, and Other Chronic Conditions