Medications and Magnesium

Common Medications That Affect Magnesium

Milk of Magnesia taken as a laxative or antacid can increase magnesium intake:

Taking the recommended dose as a laxative (2 to 4 Tbsp.) provides 990 to 1950 mg magnesium.

Taking the recommended dose as an antacid (1 to 3 tsp.) provides 165 to 500 mg magnesium.

Medications that can cause high serum magnesium:

     Lithium Carbonate

Medications that “spare” magnesium, lowering its excretion in the urine:


Listed below are medications that increase the urinary excretion of magnesium, promoting magnesium loss:

   Drugs used in heart disease

       Antiarrhythmic Drugs

       Quinidine, Sotalol, Aamiodarone, Bretylium

        Digoxin and Strophanthin

        Adrenalin and drugs that mimic its activity, such as isoproterenol



        Ethacrynic Acid


        Osmotic Agents

   Drugs to treat allergies




        Antihistamines: astemizole, terfenadine

   Drugs used in mental disorders


        thioridazine, trifluoperazine




        Amphotericin B

        Aminoglycoside group of antibiotics



   Other medications

        Antineoplastic drugs and radiation




        Hydrocortisone and other cortisone drugs

        Antacids can affect absorption of other drugs, many contain magnesium



        High dose calcium

        High dose vitamin D

        High Intake of caffeine (coffee, tea)


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